A negative antibody test does not mean that Covishield is not working — Quartz China

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Pratap Chandra, a resident of Lucknow, Uttar Pradesh, was tested for antibodies against Covid 28 days after being injected with Covishield. After the test concluded that he had no antibodies against the virus infection, he concluded that the vaccine manufacturer and the Indian Ministry of Health should be blamed.
Covishield is an AstraZeneca vaccine produced by the Serological Institute of India and is the main vaccine in the country’s ongoing immunization program. So far, most of the 216 million doses injected in India are Covishield.
The course of the law has not yet been determined, but Chandra’s complaint itself may be based on unstable scientific evidence. Experts say that antibody testing does not tell you whether the vaccine is effective.
On the one hand, the antibody test can detect whether you have been infected in the past because of the type of antibody it tests. On the other hand, vaccines induce a variety of complex antibodies, which may not be detected in rapid tests.
“After vaccination, many people will be tested for antibodies —’Oh, I want to see if it works.’ It’s actually almost irrelevant,” Luo Luo, executive director of the Global Health Institute and professor of medicine and biomedical engineering at Northwestern University. Ber Murphy told the Washington Post in February. “A lot of people have negative antibody test results, which does not mean that the vaccine is not working,” he added.
For this reason, the Centers for Disease Control and Prevention (CDC) recommends against using antibody tests after vaccination, because those tests that test specific antibodies and their interrelated tests can identify vaccine immune responses. For example, according to the CDC, these tests cannot identify more complex cellular responses, which may play a role in vaccine-induced immunity.
“If the antibody test results are negative, the person receiving the vaccine should not panic or worry, because the test cannot detect antibodies from Pfizer, Moderna, and Johnson & Johnson’s Janssen COVID-19 vaccines, which are developed against the spike protein. The virus. ,” said Fernando Martinez, director of laboratory medicine at MD Anderson Cancer Center in Texas. Vaccines like Covishield also use coronavirus spike proteins encoded in adenovirus DNA to direct cells to produce specific antibodies against the disease.


Post time: Jun-21-2021